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KPT-8602 Z-isomer

CAS No. 1642300-78-4

KPT-8602 Z-isomer( Eltanexor Z-isomer )

Catalog No. M12493 CAS No. 1642300-78-4

The Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    KPT-8602 Z-isomer
  • Note
    Research use only, not for human use.
  • Brief Description
    The Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.
  • Description
    The Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Eltanexor Z-isomer
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Exportin-1
  • Recptor
    Exportin-1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1642300-78-4
  • Formula Weight
    428.2913
  • Molecular Formula
    C17H10F6N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    O=C(N)/C(C1=CN=CN=C1)=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
  • Chemical Name
    5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αZ)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Etchin J, et al. Leukemia. 2017 Jan;31(1):143-150. 2. Hing ZA, et al. Leukemia. 2016 Dec;30(12):2364-2372. 3. Vercruysse T, et al. Clin Cancer Res. 2017 May 15;23(10):2528-2541.
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  • KPT-8602 Z-isomer

    The Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.

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